Cacna1e^tm1Ttan
Targeted Allele Detail

Summary

• Symbol: Cacna1e^tm1Ttan
• Name: calcium channel, voltage-dependent, R type, alpha 1E subunit; targeted mutation 1, Tsutomu Tanabe
• MGI ID: MGI:2179732
• Synonyms: alpha(1E)-, alpha1E-, Cav2.3^-
• Gene: Cacna1e Location: Chr1:154266477-154760247 bp, - strand Genetic Position: Chr1, 66.14 cM
• Alliance: Cacna1e^tm1Ttan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62285
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 1 of this gene was disrupted by insertion of a lacZneo-derived cassette via homologous recombination. RT-PCR and Northern blot analysis of brain RNA and Western blot analysis of brain membrane proteins from homozygous mutant animals verified the absence of gene expression. (J:62285)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacna1e Mutation: 102 strains or lines available

References

• Original: J:62285 Saegusa H, et al., Altered pain responses in mice lacking alpha 1E subunit of the voltage-dependent Ca2+ channel. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6132-7
• All: 12 reference(s)