Sv2b^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Sv2b^tm1Sud
• Name: synaptic vesicle glycoprotein 2b; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:2179737
• Synonyms: SV2B-
• Gene: Sv2b Location: Chr7:74764642-74959010 bp, - strand Genetic Position: Chr7, 43.62 cM, cytoband D1
• Alliance: Sv2b^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59180
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the first coding exon and flanking sequences. Western blot analysis on brain lysates derived from homozygous mice confirmed that no detectable encoded protein was made. (J:59180)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sv2b Mutation: 58 strains or lines available

References

• Original: J:59180 Janz R, et al., SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release. Neuron. 1999 Dec;24(4):1003-16
• All: 8 reference(s)