Kcnab2^tm1Kmc
Targeted Allele Detail

Summary

• Symbol: Kcnab2^tm1Kmc
• Name: potassium voltage-gated channel, shaker-related subfamily, beta member 2; targeted mutation 1, Ken McCormack
• MGI ID: MGI:2179738
• Synonyms: Kvbeta2-
• Gene: Kcnab2 Location: Chr4:152475201-152561991 bp, - strand Genetic Position: Chr4, 83.08 cM
• Alliance: Kcnab2^tm1Kmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75891
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neo cassette was used to disrupt the beta sheet structural element of this gene via homologous recombination resulting in a structurally unstable protein product. Immunofluorescent staining and Western blot analysis of brain lysate from homozygous mutant animals confirmed the absence of protein product. (J:75891)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnab2 Mutation: 24 strains or lines available

References

• Original: J:75891 McCormack K, et al., Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2). J Biol Chem. 2002 Apr 12;277(15):13219-28
• All: 5 reference(s)