Cited2^tm1Bha
Targeted Allele Detail

Summary

• Symbol: Cited2^tm1Bha
• Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; targeted mutation 1, Shoumo Bhattacharya
• MGI ID: MGI:2179740
• Synonyms: Cited2-
• Gene: Cited2 Location: Chr10:17598966-17601422 bp, + strand Genetic Position: Chr10, 7.18 cM, cytoband A2
• Alliance: Cited2^tm1Bha page

Magnetic resonance image (MRI) identification of septal, outflow tract and aortic arch malformations in Cited2^tm1Bha/Cited2^tm1Bha embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76593
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced 2 exons of the gene which coded for the the 5' UTR and the initiation codon. (J:76593)

Expression

In Mice Carrying this Mutation:	39 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	31 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Cited2 Mutation: 23 strains or lines available

References

• Original: J:76593 Bamforth SD, et al., Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Nat Genet. 2001 Dec;29(4):469-74
• All: 13 reference(s)