Syp^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Syp^tm1Sud
• Name: synaptophysin; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:2179741
• Synonyms: syp I deficient
• Gene: Syp Location: ChrX:7504819-7519495 bp, + strand Genetic Position: ChrX, 3.44 cM, cytoband A-D
• Alliance: Syp^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33035
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 3 and flanking sequences. Western blot analysis on brain lysates from homozygous mice confirmed that no detectable encoded protein was present. (J:33035)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syp Mutation: 22 strains or lines available

References

• Original: J:33035 McMahon HT, et al., Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4760-4
• All: 4 reference(s)