Syngr1^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Syngr1^tm1Sud
• Name: synaptogyrin 1; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:2179744
• Gene: Syngr1 Location: Chr15:79975537-80003702 bp, + strand Genetic Position: Chr15, 37.85 cM
• Alliance: Syngr1^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58559
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon II and flanking sequences, which encodes two transmembrane domains of the encoded protein. Western blot analysis on total brain protein confirmed that no detectable encoded protein was present in homozygous mice. (J:58559)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syngr1 Mutation: 41 strains or lines available

References

• Original: J:58559 Janz R, et al., Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron. 1999 Nov;24(3):687-700
• All: 3 reference(s)