Vamp2^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Vamp2^tm1Sud
• Name: vesicle-associated membrane protein 2; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:2179745
• Synonyms: syb 2 -, synaptobrevin/VAMP2^-
• Gene: Vamp2 Location: Chr11:68979354-68983207 bp, + strand Genetic Position: Chr11, 42.36 cM
• Alliance: Vamp2^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72714
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin resistance cassette was inserted 104 bp upstream of the initiation codon. Western blot analysis on brain extracts derived from homozygous mice confirmed that no detectable protein is produced from this allele. (J:72714)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vamp2 Mutation: 20 strains or lines available

References

• Original: J:72714 Schoch S, et al., SNARE function analyzed in synaptobrevin/VAMP knockout mice. Science. 2001 Nov 2;294(5544):1117-22
• All: 28 reference(s)