Dtnb^tm1Ked
Targeted Allele Detail

Summary

• Symbol: Dtnb^tm1Ked
• Name: dystrobrevin, beta; targeted mutation 1, Kay E Davies
• MGI ID: MGI:2179747
• Gene: Dtnb Location: Chr12:3622381-3831796 bp, + strand Genetic Position: Chr12, 1.88 cM
• Alliance: Dtnb^tm1Ked page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76454
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ gene followed by a neomycin resistance cassette was inserted into exon 3, which encodes part of the EF hand region present in all isoforms of the encoded protein. Western blot analysis on brain, kidney and liver tissue of homozygous mice confirmed that no detectable protein was produced from this allele. (J:76454)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dtnb Mutation: 71 strains or lines available

References

• Original: J:76454 Loh NY, et al., Role of beta-dystrobrevin in nonmuscle dystrophin-associated protein complex-like complexes in kidney and liver. Mol Cell Biol. 2001 Nov;21(21):7442-8
• All: 1 reference(s)