Scn5a^tm1Agrc
Targeted Allele Detail

Summary

• Symbol: Scn5a^tm1Agrc
• Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 1, Andrew A Grace
• MGI ID: MGI:2179753
• Synonyms: Scn5a-
• Gene: Scn5a Location: Chr9:119312474-119408082 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Scn5a^tm1Agrc page

Morphology of E10.5 control and Scn5a^tm1Agrc/Scn5a^tm1Agrc hearts

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76331
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a splice acceptor (SA)-Gfp-PGK-neo cassette via homologous recombination. RT-PCR analysis verified the lack of gene expression in homozygous mutant animals. (J:76331)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn5a Mutation: 105 strains or lines available

References

• Original: J:76331 Papadatos GA, et al., Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6210-5
• All: 16 reference(s)