Nrcam^tm1Fgr
Targeted Allele Detail

Summary

• Symbol: Nrcam^tm1Fgr
• Name: neuronal cell adhesion molecule; targeted mutation 1, Fritz G Rathjen
• MGI ID: MGI:2179756
• Gene: Nrcam Location: Chr12:44375668-44648747 bp, + strand Genetic Position: Chr12, 20.71 cM
• Alliance: Nrcam^tm1Fgr page

Nrcam^tm1Fgr/Nrcam^tm1Fgr mice develop cataracts and display reduced body weight and motor disabilities

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70385
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 4, which includes the start codon. Western blot analysis of homogenates of homozygous brains confirmed the absence of encoded protein. (J:70385)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrcam Mutation: 87 strains or lines available

References

• Original: J:70385 More MI, et al., Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation. J Cell Biol. 2001 Jul 9;154(1):187-96
• All: 4 reference(s)