Tbr1^tm1Jlr
Targeted Allele Detail

Summary

• Symbol: Tbr1^tm1Jlr
• Name: T-box brain transcription factor 1; targeted mutation 1, John L R Rubenstein
• MGI ID: MGI:2179766
• Gene: Tbr1 Location: Chr2:61633274-61644458 bp, + strand Genetic Position: Chr2, 35.56 cM
• Alliance: Tbr1^tm1Jlr page

Premature overgrowth and superabundance of subcortical axons in the brainstem of Tbr1^tm1Jlr/Tbr1^tm1Jlr Tg(Mbp-MAPT/EGFP)#Eja/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51888
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3, which encode a putative DNA-binding domain, were replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant animals were identified by Southern blot and PCR genotype analysis. (J:51888)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbr1 Mutation: 38 strains or lines available

References

• Original: J:51888 Bulfone A, et al., An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron. 1998 Dec;21(6):1273-82
• All: 21 reference(s)