Snta1^tm1Scf
Targeted Allele Detail

Summary

• Symbol: Snta1^tm1Scf
• Name: syntrophin, acidic 1; targeted mutation 1, Stanley C Froehner
• MGI ID: MGI:2179769
• Synonyms: alpha-Syn -/-, alphaSynKO
• Gene: Snta1 Location: Chr2:154218234-154250004 bp, - strand Genetic Position: Chr2, 76.52 cM
• Alliance: Snta1^tm1Scf page

Snta1^tm1Scf/Snta1^tm1Scf mice exhibit abnormal neuromuscular junctions

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76455
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 1, which encodes the first 97 amino acids including part of the PH domain and part of the PDZ domain. Northern blot analysis on RNA derived from skeletal muscle of homozygous mice demonstrated that aberrant transcripts were expressed from this allele, but immunoprecipitation experiments confirmed that no detectable encoded protein was present in skeletal muscle of homozygous mice. (J:76455)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Snta1 Mutation: 36 strains or lines available

References

• Original: J:76455 Adams ME, et al., Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin. J Cell Biol. 2000 Sep 18;150(6):1385-97
• All: 38 reference(s)