S100a8^tm1Hume
Targeted Allele Detail

Summary

• Symbol: S100a8^tm1Hume
• Name: S100 calcium binding protein A8 (calgranulin A); targeted mutation 1, David A Hume
• MGI ID: MGI:2179780
• Gene: S100a8 Location: Chr3:90576378-90577341 bp, + strand Genetic Position: Chr3, 39.9 cM, cytoband F1-F2
• Alliance: S100a8^tm1Hume page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56750
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 2, which contains the majority of the coding sequence of the gene. (J:56750)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any S100a8 Mutation: 10 strains or lines available

References

• Original: J:56750 Passey RJ, et al., A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. J Immunol. 1999 Aug 15;163(4):2209-16
• All: 2 reference(s)