Synj1^tm1Pdc
Targeted Allele Detail

Summary

• Symbol: Synj1^tm1Pdc
• Name: synaptojanin 1; targeted mutation 1, Pietro De Camilli
• MGI ID: MGI:2179801
• Gene: Synj1 Location: Chr16:90732980-90808196 bp, - strand Genetic Position: Chr16, 52.18 cM, cytoband C3-C4
• Alliance: Synj1^tm1Pdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58087
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing part of exon 1 and part of intron 1. Western blot analysis on brain tissue of homozygous mice demonstrated that no detectable protein was expressed from this allele. (J:58087)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Synj1 Mutation: 72 strains or lines available

References

• Original: J:58087 Cremona O, et al., Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell. 1999 Oct 15;99(2):179-88
• All: 16 reference(s)