Trpc2^tm1Rax
Targeted Allele Detail

Summary

• Symbol: Trpc2^tm1Rax
• Name: transient receptor potential cation channel, subfamily C, member 2; targeted mutation 1, Richard Axel
• MGI ID: MGI:2179812
• Synonyms: trp2-
• Gene: Trpc2 Location: Chr7:101732323-101745603 bp, + strand Genetic Position: Chr7, 54.71 cM, cytoband F1
• Alliance: Trpc2^tm1Rax page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76339
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 6.1 kb region of this gene, which includes exons 6-11 and encodes transmembrane domains 3-6, was replaced with a PGK-neo cassette via homologous recombination. In situ hybridization of the vomeronasal organ (VNO) from homozygous mutant animals did not detect gene transcript. Immunohistochemical staining of vomeronasal neuron cell bodies from homozygous mutant animals did not detect protein product. (J:76339)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpc2 Mutation: 98 strains or lines available

References

• Original: J:76339 Leypold BG, et al., Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6376-81
• All: 13 reference(s)