Scnn1b^tm1Wsh
Targeted Allele Detail

Summary

• Symbol: Scnn1b^tm1Wsh
• Name: sodium channel, nonvoltage-gated 1 beta; targeted mutation 1, Michael J Welsh
• MGI ID: MGI:2179819
• Synonyms: betaENaC -
• Gene: Scnn1b Location: Chr7:121464261-121517737 bp, + strand Genetic Position: Chr7, 65.07 cM
• Alliance: Scnn1b^tm1Wsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53058
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing the first exon and part of the first intron. RT-PCR analysis on lung and kidney mRNA derived from homozygous mice demonstrated that no detectable transcript is expressed from this allele. (J:53058)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scnn1b Mutation: 49 strains or lines available

References

• Original: J:53058 McDonald FJ, et al., Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1727-31
• All: 3 reference(s)