Flii^tm1Hdc
Targeted Allele Detail

Summary

• Symbol: Flii^tm1Hdc
• Name: flightless I actin binding protein; targeted mutation 1, Hugh D Campbell
• MGI ID: MGI:2179825
• Synonyms: FliI^-, Fliih^-
• Gene: Flii Location: Chr11:60604969-60618089 bp, - strand Genetic Position: Chr11, 37.81 cM, cytoband B
• Alliance: Flii^tm1Hdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76249
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Portions of exons 4 and 5 and all of intron 4 are replaced with an in-frame neo-resistance gene. Cryptic splicing around the insertion will result in a frameshift in the coding region. (J:76249)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 10 strains available Cell Lines: 0 lines available
• Carrying any Flii Mutation: 60 strains or lines available

References

• Original: J:76249 Campbell HD, et al., Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. Mol Cell Biol. 2002 May;22(10):3518-26
• All: 11 reference(s)