Asic1^tm1Wsh
Targeted Allele Detail

Summary

• Symbol: Asic1^tm1Wsh
• Name: acid-sensing ion channel 1; targeted mutation 1, Michael J Welsh
• MGI ID: MGI:2179834
• Synonyms: ASIC^-, ASIC1^-, ASIC1a^-
• Gene: Asic1 Location: Chr15:99568249-99599011 bp, + strand Genetic Position: Chr15, 56.13 cM, cytoband F3
• Alliance: Asic1^tm1Wsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76361
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 of this gene was replaced with a PGK-neo cassette via homologous recombination resulting in the deletion of the first 121 amino acids, which includes the intracellular N terminus, the first transmembrane domain, and a portion of the extracellular domain. Immunoprecipitation and Western blot analysis failed to detect protein in extracts from brain and hippocampus of homozygous mutant animals. (J:76361)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Asic1 Mutation: 42 strains or lines available

References

• Original: J:76361 Wemmie JA, et al., The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron. 2002 Apr 25;34(3):463-77
• All: 61 reference(s)