F2rl1^tm1Cgh
Targeted Allele Detail

Summary

• Symbol: F2rl1^tm1Cgh
• Name: F2R like trypsin receptor 1; targeted mutation 1, Shaun R Coughlin
• MGI ID: MGI:2179844
• Synonyms: F2rl1^tm1Kley, PAR-2^-, PAR2-
• Gene: F2rl1 Location: Chr13:95648240-95661735 bp, - strand Genetic Position: Chr13, 49.53 cM
• Alliance: F2rl1^tm1Cgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76626
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neomycin resistance cassette via homologous recombination. Homozygous mutant animals were identified by Southern blot analysis. (J:76626)

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any F2rl1 Mutation: 60 strains or lines available

References

• Original: J:76626 Lindner JR, et al., Delayed onset of inflammation in protease-activated receptor-2-deficient mice. J Immunol. 2000 Dec 1;165(11):6504-10
• All: 31 reference(s)