Ptger2^tm1Brey
Targeted Allele Detail

Summary

• Symbol: Ptger2^tm1Brey
• Name: prostaglandin E receptor 2 (subtype EP2); targeted mutation 1, Richard M Breyer
• MGI ID: MGI:2179967
• Synonyms: EP2-
• Gene: Ptger2 Location: Chr14:45225652-45241277 bp, + strand Genetic Position: Chr14, 22.68 cM
• Alliance: Ptger2^tm1Brey page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53646
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced part of the amino terminal coding sequence, including 420 bp from the ATG start codon to codon 140. (J:53646)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Ptger2 Mutation: 31 strains or lines available

References

• Original: J:53646 Kennedy CR, et al., Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nat Med. 1999 Feb;5(2):217-20
• All: 48 reference(s)