Cd24a^tm1Pjln
Targeted Allele Detail

Summary

• Symbol: Cd24a^tm1Pjln
• Name: CD24a antigen; targeted mutation 1, P J Nielsen
• MGI ID: MGI:2179996
• Synonyms: CD24^-, HSA-
• Gene: Cd24a Location: Chr10:43454433-43460261 bp, + strand Genetic Position: Chr10, 23.01 cM
• Alliance: Cd24a^tm1Pjln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76695
• Parent Cell Line: N1 (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter region and exon 1 were replaced with a neo cassette via homologous recombination. Gene transcripts were absent in spleen from homozygous mutant animals as determined by Northern blot analysis. (J:76695, J:76970)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cd24a^tm1Pjln

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd24a Mutation: 18 strains or lines available

References

• Original: J:76695 Nielsen PJ, et al., Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice. Blood. 1997 Feb 1;89(3):1058-67
• All: 36 reference(s)