Arhgap5^tm1Jset
Targeted Allele Detail

Summary

• Symbol: Arhgap5^tm1Jset
• Name: Rho GTPase activating protein 5; targeted mutation 1, Jeffrey Settleman
• MGI ID: MGI:2179998
• Synonyms: p190 B RhoGAP-
• Gene: Arhgap5 Location: Chr12:52550755-52618758 bp, + strand Genetic Position: Chr12, 22.16 cM
• Alliance: Arhgap5^tm1Jset page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76484
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neo cassette is inserted in reverse transcriptional orientation relative to the coding sequence, disrupting the gene immediately upstream of the GTPase domain. Immunoblot of embryonic tissue probed with antisera failed to detect protein in homozygous mutant animals. (J:76484)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgap5 Mutation: 43 strains or lines available

References

• Original: J:76484 Sordella R, et al., Modulation of CREB Activity by the Rho GTPase Regulates Cell and Organism Size during Mouse Embryonic Development. Dev Cell. 2002 May;2(5):553-65
• All: 8 reference(s)