Lcp2^tm1Gak
Targeted Allele Detail

Summary

• Symbol: Lcp2^tm1Gak
• Name: lymphocyte cytosolic protein 2; targeted mutation 1, Gary A Koretzky
• MGI ID: MGI:2180002
• Synonyms: SLP-76-
• Gene: Lcp2 Location: Chr11:33996928-34042281 bp, + strand Genetic Position: Chr11, 19.43 cM
• Alliance: Lcp2^tm1Gak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76697
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Approximately 360 bp of the gene, including part of exon 1 and the translation initiation site, was replaced with a neo cassette via homologous recombination. RT-PCR analysis of homozygous mutant animals verified the absence of gene expression. Western blot and immunohistochemistry of spleen from homozygous mutant animals did not detect protein product. (J:76697)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lcp2 Mutation: 41 strains or lines available

References

• Original: J:76697 Clements JL, et al., Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science. 1998 Jul 17;281(5375):416-9
• All: 33 reference(s)