Grap2^tm1Amch
Targeted Allele Detail

Summary

• Symbol: Grap2^tm1Amch
• Name: GRB2-related adaptor protein 2; targeted mutation 1, Alec M Cheng
• MGI ID: MGI:2180009
• Synonyms: GADS-
• Gene: Grap2 Location: Chr15:80456798-80537055 bp, + strand Genetic Position: Chr15, 37.88 cM, cytoband E2
• Alliance: Grap2^tm1Amch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76696
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Four exons encoding the C-terminal portion of the SH2 domain, the linker region, and the C-terminal SH3 domain were replaced with a neomycin cassette via homologous recombination. Protein product is absent in spleen from homozygous mutant animals as determined by Western blot analysis. (J:76696)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grap2 Mutation: 23 strains or lines available

References

• Original: J:76696 Yoder J, et al., Requirement for the SLP-76 adaptor GADS in T cell development. Science. 2001 Mar 9;291(5510):1987-91
• All: 8 reference(s)