Nr5a1^tm2Klp
Targeted Allele Detail

Summary

• Symbol: Nr5a1^tm2Klp
• Name: nuclear receptor subfamily 5, group A, member 1; targeted mutation 2, Keith L Parker
• MGI ID: MGI:2180013
• Synonyms: F, Sf1^Fl
• Gene: Nr5a1 Location: Chr2:38582668-38604554 bp, - strand Genetic Position: Chr2, 24.42 cM
• Alliance: Nr5a1^tm2Klp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66593
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted into an intron 5' to the last coding exon, and a loxP site followed by a neomycin resistance cassette was inserted 3' to this exon. This mutation flanks sequences encoding motifs essential for transcriptional activity as well as the transcription termination and polyadenyulation sequences. (J:66593)

Disease models

Expression

In Mice Carrying this Mutation:	28 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	26 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nr5a1 Mutation: 30 strains or lines available

References

• Original: J:66593 Zhao L, et al., Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development. 2001 Jan;128(2):147-54
• All: 26 reference(s)