Kcnj8^tm1Sse
Targeted Allele Detail

Summary

• Symbol: Kcnj8^tm1Sse
• Name: potassium inwardly-rectifying channel, subfamily J, member 8; targeted mutation 1, Susumu Seino
• MGI ID: MGI:2180015
• Synonyms: Kir6.1-null
• Gene: Kcnj8 Location: Chr6:142510563-142517340 bp, - strand Genetic Position: Chr6, 74.31 cM
• Alliance: Kcnj8^tm1Sse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76195
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of intron 2 and exon 3, which encode the pore-forming region of the ion channel, were replaced with a neomycin resistance cassette via homologous recombination. Lack of gene expression in brain, heart, and liver of homozygous mutant animals was confirmed via Northern blot analysis. (J:76195)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj8 Mutation: 34 strains or lines available

References

• Original: J:76195 Miki T, et al., Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. Nat Med. 2002 May;8(5):466-72
• All: 12 reference(s)