Ltbp3^tm1Bdvc
Targeted Allele Detail

Summary

• Symbol: Ltbp3^tm1Bdvc
• Name: latent transforming growth factor beta binding protein 3; targeted mutation 1, Branka Dabovic
• MGI ID: MGI:2180017
• Synonyms: Ltbp-3-null
• Gene: Ltbp3 Location: Chr19:5790932-5808560 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B
• Alliance: Ltbp3^tm1Bdvc page

Skeletal abnormalities in Ltbp3^tm1Bdvc/Ltbp3^tm1Bdvc mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76213
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two exons of this gene spanning nucleotides 278-807 were replaced with a neo resistance cassette, causing a frameshift in the ORF resulting in premature translation termination and deletion of the first EGF-like repeat, the pro-gly-rich region, and the beginning of the first 8-cys domain. Northern blot analysis of lung from homozygous mutant animals using a probe corresponding to the deleted exons failed to detect transcripts. (J:76213)

Disease models

Expression

In Structures Affected by this Mutation:

24 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltbp3 Mutation: 59 strains or lines available

References

• Original: J:76213 Dabovic B, et al., Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability. J Cell Biol. 2002 Jan 21;156(2):227-32
• All: 13 reference(s)