Abcb1a^tm1Bor
Targeted Allele Detail

Summary

• Symbol: Abcb1a^tm1Bor
• Name: ATP-binding cassette, sub-family B member 1A; targeted mutation 1, Piet Borst
• MGI ID: MGI:2180054
• Synonyms: mdr1a-
• Gene: Abcb1a Location: Chr5:8710077-8798575 bp, + strand Genetic Position: Chr5, 3.43 cM
• Alliance: Abcb1a^tm1Bor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:18554
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.6-kb fragment containing exons 6 and 7 and encoding the extracellular, transmembrane, and cytoplasmic domains, was replaced by the insertion of a hygromycin cassette. While low levels of transcript were detected in the intestines of homozygous mutant mice by RNAase protection assays, immunoblot analysis showed an absence of protein expression. (J:18554)

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Abcb1a^tm1Bor

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Abcb1a Mutation: 93 strains or lines available

References

• Original: J:18554 Schinkel AH, et al., Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell. 1994 May 20;77(4):491-502
• All: 112 reference(s)