Ntf3^tm1Tojo
Targeted Allele Detail

Summary

• Symbol: Ntf3^tm1Tojo
• Name: neurotrophin 3; targeted mutation 1, Hideaki Tojo
• MGI ID: MGI:2180062
• Synonyms: NT-3(-)
• Gene: Ntf3 Location: Chr6:126078375-126143703 bp, - strand Genetic Position: Chr6, 60.45 cM
• Alliance: Ntf3^tm1Tojo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22369
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6 or DBA/2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo-lacZ cassette via homologous recombination. Northern blot confirmed the absence of gene expression in homozygous mutant animals. (J:22369)

Expression

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntf3 Mutation: 24 strains or lines available

Notes

ES cell line = BDM-3 (F1 cross of C57BL/6 and DBA/2).

References

• Original: J:22369 Tojo H, et al., Targeted disruption of the neurotrophin-3 gene with lacZ induces loss of trkC-positive neurons in sensory ganglia but not in spinal cords. Brain Res. 1995 Jan 16;669(2):163-75
• All: 1 reference(s)