Egr3^tm1Jmi
Targeted Allele Detail

Summary

• Symbol: Egr3^tm1Jmi
• Name: early growth response 3; targeted mutation 1, Jeffrey Milbrandt
• MGI ID: MGI:2180063
• Synonyms: Egr-3-, Egr3-
• Gene: Egr3 Location: Chr14:70314766-70320062 bp, + strand Genetic Position: Chr14, 36.2 cM, cytoband D1
• Alliance: Egr3^tm1Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49575
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A 0.9 kb region of the gene encoding the zinc-finger domain and C-terminus of the protein was disrupted by insertion of a neomycin resistance cassette. Northern and Western blot of brain from homozygous mutant animals failed to detect gene expression. (J:49575)

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Egr3 Mutation: 17 strains or lines available

References

• Original: J:49575 Tourtellotte WG, et al., Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nat Genet. 1998 Sep;20(1):87-91
• All: 45 reference(s)