Actc1^tm1Jll
Targeted Allele Detail

Summary

• Symbol: Actc1^tm1Jll
• Name: actin, alpha, cardiac muscle 1; targeted mutation 1, James Lessard
• MGI ID: MGI:2180072
• Synonyms: cardiac alpha-actin^-
• Gene: Actc1 Location: Chr2:113877763-113883356 bp, - strand Genetic Position: Chr2, 57.55 cM
• Alliance: Actc1^tm1Jll page

Myofibrillar disarray in newborn Actc1^tm1Jll/Actc1^tm1Jll hearts

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40165
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting construct containing HPRT was used to disrupt exon 2. A truncated transcript was detected in extracts from the hearts of homozygous mutant mice, but was shown to be non-coding by the lack of either a normal or truncated peptide in Western blots. (J:40165)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Actc1 Mutation: 24 strains or lines available

References

• Original: J:40165 Kumar A, et al., Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4406-11
• All: 3 reference(s)