Acadvl^tm1Uab
Targeted Allele Detail

Summary

• Symbol: Acadvl^tm1Uab
• Name: acyl-Coenzyme A dehydrogenase, very long chain; targeted mutation 1, University of Alabama
• MGI ID: MGI:2180080
• Synonyms: VLCAD^-
• Gene: Acadvl Location: Chr11:69901009-69906237 bp, - strand Genetic Position: Chr11, 42.96 cM, cytoband B2-B5
• Alliance: Acadvl^tm1Uab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72193
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette was used to replace exons 7 through 19 and the first 33 nucleotides of exon 20. Western analysis of the livers of homozygous mutant mice showed an absence of protein. (J:72193)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acadvl Mutation: 31 strains or lines available

References

• Original: J:72193 Cox KB, et al., Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase deficiency in the mouse. Hum Mol Genet. 2001 Sep 15;10(19):2069-77
• All: 14 reference(s)