Dnah5^Tg1Htz
Transgenic Allele Detail

Summary

• Symbol: Dnah5^Tg1Htz
• Name: dynein, axonemal, heavy chain 5; transgene insertion 1, Nathaniel Heintz
• MGI ID: MGI:2180081
• Synonyms: Mdnah5 -
• Gene: Dnah5 Location: Chr15:28203898-28472198 bp, + strand Genetic Position: Chr15, 10.9 cM
• Alliance: Dnah5^Tg1Htz page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA/J)F1

Transgene description

• Transgene Type: Transgenic
• Mutation: Insertion
• Mutation details: This mutation resulted from the random integration of a transgene (not identified in paper). RT-PCR analysis demonstrated that a transcript with the transgene replacing sequences between exons 16 and 22 was expressed, resulting in the generation of a stop codon at the start of the transgene. The predicted translated product of this fusion transcript lacks all of the known functional domains of the protein. (J:76189)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnah5 Mutation: 252 strains or lines available

References

• Original: J:76189 Ibanez-Tallon I, et al., Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus. Hum Mol Genet. 2002 Mar 15;11(6):715-21
• All: 2 reference(s)