Acp2^tm1Psa
Targeted Allele Detail

Summary

• Symbol: Acp2^tm1Psa
• Name: acid phosphatase 2, lysosomal; targeted mutation 1, Paul Saftig
• MGI ID: MGI:2180084
• Synonyms: LAP^-
• Gene: Acp2 Location: Chr2:91033230-91044443 bp, + strand Genetic Position: Chr2, 50.54 cM
• Alliance: Acp2^tm1Psa page

Acp2^tm1Psa/Acp2^tm1Psa mice develop lower thoracic kyphosis and upper thoracic lordosis with age

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41986
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 7, introducing a translational stop codon into the open reading frame. Northern blot analysis showed an absence of expression in the livers and kidneys of homozygous mice. No enzymatic activity was detected in assays of kidney and spleen homogenates from homozygotes. (J:41986)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acp2 Mutation: 27 strains or lines available

References

• Original: J:41986 Saftig P, et al., Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system. J Biol Chem. 1997 Jul 25;272(30):18628-35
• All: 4 reference(s)