Acp5^tm1Ahdm
Targeted Allele Detail

Summary

• Symbol: Acp5^tm1Ahdm
• Name: acid phosphatase 5, tartrate resistant; targeted mutation 1, Addenbrookes Hospital Department of Medicine
• MGI ID: MGI:2180086
• Synonyms: Acp5-, TRACP^-, TRAP-
• Gene: Acp5 Location: Chr9:22038023-22047007 bp, - strand Genetic Position: Chr9, 8.38 cM
• Alliance: Acp5^tm1Ahdm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36232
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2, which encodes the conserved putative iron-binding domain, was disrupted by the insertion of a neomycin resistance gene. Acid phosphatase activity specific to this osteoclast isozyme was assayed and found to be undetectable in bone homogenates from homozygous mutant mice. Further analysis using histochemical staining confirmed the absence of a functional enzyme. (J:36232)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acp5 Mutation: 21 strains or lines available

References

• Original: J:36232 Hayman AR, et al., Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis. Development. 1996 Oct;122(10):3151-62
• All: 8 reference(s)