Nr5a1^tm2.1Klp
Targeted Allele Detail

Summary

• Symbol: Nr5a1^tm2.1Klp
• Name: nuclear receptor subfamily 5, group A, member 1; targeted mutation 2.1, Keith L Parker
• MGI ID: MGI:2180092
• Synonyms: R
• Gene: Nr5a1 Location: Chr2:38582668-38604554 bp, - strand Genetic Position: Chr2, 24.42 cM
• Alliance: Nr5a1^tm2.1Klp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66593
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This heritable allele is a derivative of Nr5a1^tm2Klp in which the loxP-flanked sequences were deleted by ectopic Cre recombinase activity in germ cells. (J:66593)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr5a1 Mutation: 30 strains or lines available

References

• Original: J:66593 Zhao L, et al., Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development. 2001 Jan;128(2):147-54
• All: 2 reference(s)