Adam9^tm1Bbl
Targeted Allele Detail

Summary

• Symbol: Adam9^tm1Bbl
• Name: ADAM metallopeptidase domain 9; targeted mutation 1, Carl Blobel
• MGI ID: MGI:2180096
• Synonyms: mdc9^-
• Gene: Adam9 Location: Chr8:25439627-25506943 bp, - strand Genetic Position: Chr8, 13.7 cM
• Alliance: Adam9^tm1Bbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74655
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into the exon encoding amino acids 32 through 66. Protein expression was undetectable in lung and brain tissue isolated from homozygous mutants and in tissue from homozygous mutant embryos. (J:74655)

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adam9 Mutation: 45 strains or lines available

References

• Original: J:74655 Weskamp G, et al., Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life. Mol Cell Biol. 2002 Mar;22(5):1537-44
• All: 16 reference(s)