Adh1^tm1Gdu
Targeted Allele Detail

Summary

• Symbol: Adh1^tm1Gdu
• Name: alcohol dehydrogenase 1 (class I); targeted mutation 1, Gregg Duester
• MGI ID: MGI:2180100
• Synonyms: Adh1^-
• Gene: Adh1 Location: Chr3:137983346-137996459 bp, + strand Genetic Position: Chr3, 64.16 cM
• Alliance: Adh1^tm1Gdu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55555
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exons 7 through 9 were replaced with a PGK-neo gene downstream of exon 6. Transcripts were undetectable in total RNA extracts from the liver, kidney, and epididymis of homozygous mice by Northern analysis. A lack of protein expression was confirmed by Western blot analysis. (J:55555)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adh1 Mutation: 32 strains or lines available

References

• Original: J:55555 Deltour L, et al., Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid. J Biol Chem. 1999 Jun 11;274(24):16796-801
• All: 5 reference(s)