Adh5^tm1Gdu
Targeted Allele Detail

Summary

• Symbol: Adh5^tm1Gdu
• Name: alcohol dehydrogenase 5 (class III), chi polypeptide; targeted mutation 1, Gregg Duester
• MGI ID: MGI:2180101
• Synonyms: Adh3^-
• Gene: Adh5 Location: Chr3:138148854-138161260 bp, + strand Genetic Position: Chr3, 64.26 cM
• Alliance: Adh5^tm1Gdu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55555
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A construct containing a PGK-neo gene upstream of exon 5 was used to replace exons 1 through 4. Transcripts were undetectable in total RNA extracts from the liver, kidney, and epididymis of homozygous mutant mice by Northern blot analysis. A lack of protein expression was confirmed by Western blot analysis. (J:55555)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adh5 Mutation: 30 strains or lines available

References

• Original: J:55555 Deltour L, et al., Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid. J Biol Chem. 1999 Jun 11;274(24):16796-801
• All: 3 reference(s)