Adh7^tm1Gdu
Targeted Allele Detail

Summary

• Symbol: Adh7^tm1Gdu
• Name: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; targeted mutation 1, Gregg Duester
• MGI ID: MGI:2180102
• Synonyms: Adh4^-
• Gene: Adh7 Location: Chr3:137923521-137939143 bp, + strand Genetic Position: Chr3, 64.13 cM
• Alliance: Adh7^tm1Gdu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56168
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced the promoter and exons 1 through 6. Northern blot analysis showed an absence of transcript in extracts isolated from the stomach and skin tissue of homozygous mutant mice. Western blot analysis confirmed a lack of encoded protein and normal levels of other alcohol dehydrogenases in homozygous mutant animals. (J:56168)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adh7 Mutation: 23 strains or lines available

References

• Original: J:56168 Deltour L, et al., Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice. Dev Genet. 1999;25(1):1-10
• All: 7 reference(s)