Tlx3^tm1Sjk
Targeted Allele Detail

Summary

• Symbol: Tlx3^tm1Sjk
• Name: T cell leukemia, homeobox 3; targeted mutation 1, Stanley J Korsmeyer
• MGI ID: MGI:2180105
• Synonyms: Rnx-, Tlx3^-
• Gene: Tlx3 Location: Chr11:33150752-33153589 bp, - strand Genetic Position: Chr11, 19.21 cM, cytoband A5
• Alliance: Tlx3^tm1Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60751
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette was inserted into exon 1. RNA in situ analysis confirmed the lack of gene expression in homozygous mice. (J:60751)

Disease models

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlx3 Mutation: 14 strains or lines available

References

• Original: J:60751 Shirasawa S, et al., Rnx deficiency results in congenital central hypoventilation. Nat Genet. 2000 Mar;24(3):287-90
• All: 14 reference(s)