Nefm^tm1Jpj
Targeted Allele Detail

Summary

• Symbol: Nefm^tm1Jpj
• Name: neurofilament, medium polypeptide; targeted mutation 1, Jean-Pierre Julien
• MGI ID: MGI:2180106
• Synonyms: NF-M-
• Gene: Nefm Location: Chr14:68356994-68362453 bp, - strand Genetic Position: Chr14, 35.46 cM
• Alliance: Nefm^tm1Jpj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56931
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was verified in Northern blots of brain from homozygous mutant animals. (J:56931)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nefm Mutation: 28 strains or lines available

References

• Original: J:56931 Jacomy H, et al., Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits. J Neurochem. 1999 Sep;73(3):972-84
• All: 9 reference(s)