Asic2^tm1Wsh
Targeted Allele Detail

Summary

• Symbol: Asic2^tm1Wsh
• Name: acid-sensing ion channel 2; targeted mutation 1, Michael J Welsh
• MGI ID: MGI:2180111
• Synonyms: ASIC2^-, BNC1^-
• Gene: Asic2 Location: Chr11:80770989-81859222 bp, - strand Genetic Position: Chr11, 48.43 cM
• Alliance: Asic2^tm1Wsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76712
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted to disrupt two exons encoding the second transmembrane domain, which is common to both splice variants, as well as a channel pore. Transcripts were not detected in the brains of homozygous mutant mice. Neither in situ hybridization nor immunostaining detected protein in the large or small dorsal root ganglion neurons of homozygous animals. (J:76712)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Asic2 Mutation: 37 strains or lines available

References

• Original: J:76712 Price MP, et al., The mammalian sodium channel BNC1 is required for normal touch sensation. Nature. 2000 Oct 26;407(6807):1007-11
• All: 35 reference(s)