Aebp1^tm1Mdl
Targeted Allele Detail

Summary

• Symbol: Aebp1^tm1Mdl
• Name: AE binding protein 1; targeted mutation 1, Matthew D Layne
• MGI ID: MGI:2180115
• Synonyms: ACLP^-
• Gene: Aebp1 Location: Chr11:5811947-5822088 bp, + strand Genetic Position: Chr11, 3.88 cM
• Alliance: Aebp1^tm1Mdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70416
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette was used to replace exons 7 through the majority of 16. The deleted region encodes the discoidin domain and a portion of the carboxypeptidase-like domain. Northern and Western analyses of homozygous embryos showed an absence of normal mRNA and protein expression, respectively. Because the antiserum used for the Western analysis was raised against the C-terminus, it is possible that a truncated protein was present in heterozygous mutants, though the authors believe that there is no gain-of-function. (J:70416)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aebp1 Mutation: 34 strains or lines available

References

• Original: J:70416 Layne MD, et al., Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein. Mol Cell Biol. 2001 Aug;21(15):5256-61
• All: 4 reference(s)