Pzp^tm1Vln
Targeted Allele Detail

Summary

• Symbol: Pzp^tm1Vln
• Name: PZP, alpha-2-macroglobulin like; targeted mutation 1, Fred Van Leuven
• MGI ID: MGI:2180117
• Synonyms: MAM^-
• Gene: Pzp Location: Chr6:128460530-128503683 bp, - strand Genetic Position: Chr6, 63.02 cM, cytoband F1-G3
• Alliance: Pzp^tm1Vln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28328
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A construct was created by replacing 0.7-kb of intron 17 with PKC-hygro. Northern analysis of RNA isolated from the livers of homozygous mice showed an absence of transcript. Rocket immunoelectrophoresis also showed no expression. (J:28328)

Expression

In Mice Carrying this Mutation:	62 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pzp Mutation: 80 strains or lines available

References

• Original: J:28328 Umans L, et al., Targeted inactivation of the mouse alpha 2-macroglobulin gene. J Biol Chem. 1995 Aug 25;270(34):19778-85
• All: 7 reference(s)