Mug1^tm1Vln
Targeted Allele Detail

Summary

• Symbol: Mug1^tm1Vln
• Name: murinoglobulin 1; targeted mutation 1, Fred Van Leuven
• MGI ID: MGI:2180118
• Synonyms: Mug^-, MUG-1^-
• Gene: Mug1 Location: Chr6:121815500-121866016 bp, + strand Genetic Position: Chr6, 57.52 cM, cytoband F2
• Alliance: Mug1^tm1Vln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57485
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.9-kb fragment containing exon 18 and 108 nucleotides of exon 19 was replaced by the insertion of a PKC-hygro cassette. Northern analysis of RNA isolated from the livers of homozygous mutant mice showed an absence of normal transcript. Homozygous mice were also shown to lack protein expression. (J:57485)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mug1 Mutation: 115 strains or lines available

References

• Original: J:57485 Umans L, et al., alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis. Am J Pathol. 1999 Sep;155(3):983-93
• All: 1 reference(s)