Adcyap1r1^tm1.1Gsc
Targeted Allele Detail

Summary

• Symbol: Adcyap1r1^tm1.1Gsc
• Name: adenylate cyclase activating polypeptide 1 receptor 1; targeted mutation 1.1, Gunther Schutz
• MGI ID: MGI:2180119
• Synonyms: PAC1^-
• Gene: Adcyap1r1 Location: Chr6:55428963-55478436 bp, + strand Genetic Position: Chr6, 27.38 cM, cytoband B3
• Alliance: Adcyap1r1^tm1.1Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76715
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: ES cells were transfected with a construct in which a LoxP site was inserted just upstream of exon 11 and a floxed neomycin-thymidine-kinase region inserted downstream. The transient expression of cre recombinase in ES cells resulted in the excision of the selection genes and exon 11, which encodes a portion of the transmembrane domain IV and is included in all known splice variants. (J:76715)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adcyap1r1 Mutation: 34 strains or lines available

References

• Original: J:76715 Otto C, et al., Impairment of mossy fiber long-term potentiation and associative learning in pituitary adenylate cyclase activating polypeptide type I receptor-deficient mice. J Neurosci. 2001 Aug 1;21(15):5520-7
• All: 4 reference(s)