Adora1^tm1Bbf
Targeted Allele Detail

Summary

• Symbol: Adora1^tm1Bbf
• Name: adenosine A1 receptor; targeted mutation 1, Bertil B Fredholm
• MGI ID: MGI:2180136
• Synonyms: A1AR-, A1-KO, A1R^-
• Gene: Adora1 Location: Chr1:134126963-134163169 bp, - strand Genetic Position: Chr1, 58.15 cM, cytoband E4
• Alliance: Adora1^tm1Bbf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70664
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced most of the coding region and a portion of the of the 3' flanking region of the targeted exon. An absence of the normal protein was observed using in situ hybridization and autoradiographic analysis using a labeled ligand, DPCPX. (J:70664)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adora1 Mutation: 23 strains or lines available

References

• Original: J:70664 Johansson B, et al., Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9407-12
• All: 56 reference(s)