Cacna1d^tm1Hssh
Targeted Allele Detail

Summary

• Symbol: Cacna1d^tm1Hssh
• Name: calcium channel, voltage-dependent, L type, alpha 1D subunit; targeted mutation 1, Hee-Sup Shin
• MGI ID: MGI:2180138
• Synonyms: alpha(1D)-, Cav1.3^-
• Gene: Cacna1d Location: Chr14:29761898-30213113 bp, - strand Genetic Position: Chr14, 18.43 cM, cytoband B
• Alliance: Cacna1d^tm1Hssh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72316
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 and all of exon 2 was replaced with an IRES-BetaGal-polyA-PGK-neo cassette via homologous recombination. Western blot of cerebral membrane fractions and immunohistochemical staining of pancreas sections from homozygous mutant animals did not detect protein product. Unexpectedly, lacZ staining was not detected in mutant animals. (J:72316)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1d Mutation: 119 strains or lines available

References

• Original: J:72316 Namkung Y, et al., Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation. J Clin Invest. 2001 Oct;108(7):1015-22
• All: 7 reference(s)