Angpt1^tm2Sato
Targeted Allele Detail

Summary

• Symbol: Angpt1^tm2Sato
• Name: angiopoietin 1; targeted mutation 2, Thomas Sato
• MGI ID: MGI:2180145
• Synonyms: Mu2
• Gene: Angpt1 Location: Chr15:42288119-42540373 bp, - strand Genetic Position: Chr15, 16.69 cM
• Alliance: Angpt1^tm2Sato page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37459
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A promoterless lacZ-neo construct was used to disrupt exon 1, which is essential for function. Northern blot analysis using a probe for exon 1 revealed an absence of normal transcript in homozygous mutant embryos, however, lacZ was expressed from the endogenous promoter. (J:37459)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angpt1 Mutation: 35 strains or lines available

References

• Original: J:37459 Suri C, et al., Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell. 1996 Dec 27;87(7):1171-80
• All: 2 reference(s)